MedChemExpress (MCE)

Inhibitors | Agonists | Recombinant Proteins | Dyes | Assay Kits | Compound Libraries | Drug Screening | PCR | Cell Culture Reagents | Custom Synthesis, Screening, ADC, PROTAC Solutions

Current MCE promotions

Contact us now to request your free sample. This promotion is valid until 31-12-2026.

Promotion Terms and Conditions

• The promotion cannot be applied retroactively.
• Standard shipping costs (€38,-) still apply.
• Bio-Connect reserves the right to modify, cancel, or withdraw this promotion at any time.


About MedChemExpress (MCE)

MedChemExpress is a leading global supplier in the life sciences research field, dedicated to empowering researchers with high-quality research chemicals and biological tools. The company serves a diverse customer base, including universities, research institutions, and pharmaceutical companies, offering an extensive product portfolio and professional services designed to accelerate discovery and advance scientific understanding.

Comprehensive product portfolio:

With decades of dedication to the industry, MedChemExpress boasts more than 200,000+ bioactive molecules, covering a wide range of signaling pathways and research areas including Target and Disease Mechanism Studies, Detection, Analysis, and Quality Control, Disease Modeling and Drug Screening, Stem Cell Research and Cell Therapy, Gene Therapy, and other drug discovery fields.

  • Target and Disease Mechanism Studies:Inhibitors & Agonists, PROTAC, ADC, Recombinant Protein, Inhibitory Antibodies, Peptides, Induced Disease Models Products, Animal Feed Products;
  • Detection, Analysis, and Quality Control:Isotope-Labeled Compounds, Fluorescent Dye, Reference Standards, Antibodies, Enzymes, Kits;
  • Stem Cell Research and Cell Therapy: GMP small molecules, Organoid-related proteins, Matrigel, Culture medium, Serum;
  • Gene Therapy: Small RNA, Liposomes, Adjuvants, Restriction Endonucleases, PCR, qPCR Kits.

One-Stop AI-based Compound Screening Platform

MedChemExpress One-Stop Compound Screening Platform supplies more than 200 screening libraries and a variety of compounds and phenotypic screening services. These services include DNA-encoded compound library screening, virtual screening, high-throughput screening (HTS), ion channel detection, kinase screening & profiling, phenotypic screening, affinity mass spectrometry screening, customized compound synthesis, structural optimization and analysis services, etc. Our commitment is to continuously advance our platform capabilities. By creating a one-stop drug discovery service for scientific research, we aim to unlock infinite possibilities for innovation.

Industry-Leading Bioinformatics

  • Targets and signaling pathways: JAK, STAT, PD-1/PD-L1, KRAS, STING, Ferroptosis, etc.
  • Authoritative support: In vivo/In vitro experimental protocols from the literature
  • Dynamic data: 150,000+ solubility measurements, tens of millions of genetic information entries, Clinical/approval tracking
  • Wide applications: Pharmacology and biological research, covering 400+ disease/field studies, including cancer, neurology, inflammation, metabolism, stem cells, etc.
  • 7×24 Professional Services: Having served over one million customers

Robust Multi-Level Quality Control

  • International Standards: Strict compliance with ISO 9001:2015, ISO 9001, ISO 17025, ICH Q7, quality and environmental management systems
  • Complete Platform: 400+ precision instruments, 1,000 R&D and analytical staff
  • Comprehensive Testing: NMR, HPLC, LC-MS, IR, Elemental analysis, etc.
  • Biovalidation Platform: Four Major Platforms (Molecular/Protein/Cell/In Vivo Experiments) Supporting Drug Efficacy Evaluation

Global Business and Warehousing Center

A global warehouse center covering North America, China, Europe, Japan, and other regions. With dozens of warehouses, they achieve next-day delivery in 90% of regions and quickly respond to global customer needs.

Publications

  • Nature. Published online December 2, 2021.

    Kagawa H, Javali A, Khoei HH, et al. Human blastoids model blastocyst development and implantation.

  • Cell. 2021;184(21):5375-5390.e16.

    Manford AG, Mena EL, Shih KY, et al. Structural basis and regulation of the reductive stress response.

  • Nature. 2021;596(7871):291-295.

    Monteys AM, Hundley AA, Ranum PT, et al. Regulated control of gene therapies by drug-induced splicing.

  • Cell. 2021;184(17):4579-4592.e24.

    Bosch B, DeJesus MA, Poulton NC, et al. Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis.

  • Nature. 2021;594(7862):277-282.

    Pan Y, Hysinger JD, Barron T, et al. NF1 mutation drives neuronal activity-dependent initiation of optic glioma.

  • Cell. 2021;184(13):3528-3541.e12.

    Bi G, Su M, Li N, et al. The ZAR1 resistosome is a calcium-permeable channel triggering plant immune signaling.

  • Nature. 2021;591(7850):477-481.

    Tigano M, Vargas DC, Tremblay-Belzile S, Fu Y, Sfeir A. Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance.

  • Cell. 2021;184(4):943-956.e18.

    Xiao P, Yan W, Gou L, et al. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.

  • Science. 2021;371(6533):eabb2224.

    Yan R, Cao P, Song W, et al. A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.

  • Nature. 2021;590(7847):612-617.

    Lee JH, Kim JY, Noh S, et al. Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis.

Videos

MCE provides a one-stop solution for drug screening to accelerate early drug discovery!

Custom services

MedChemExpress (MCE) provides a full-stack, one-stop custom R&D service portfolio covering drug discovery, custom synthesis, biotech preparation, and pharmaceutical screening. Tailored for global academic research and preclinical pharmaceutical development, MCE delivers high-quality, customizable, and compliant solutions to accelerate biomedical research and drug development progress.

1. Full-range Custom Synthesis & Preparation Services
MCE supports customized development of diverse chemical and biomolecular products, covering most mainstream research materials in life science and pharmaceutical R&D:

  • Small molecule custom synthesis: Including inhibitors, agonists, antagonists, natural products, metabolites, steroids, and innovative complex skeleton molecules. It specializes in multi-step complex synthesis, route optimization, and mass production from milligram to kilogram scale.
  • ADC & PROTAC customized services: Professional custom design and synthesis of ADC toxins, linkers, drug-linker conjugates, and various PROTAC molecules, supporting high-difficulty structural construction and purification.
  • Biomolecule customization: Covers polypeptide synthesis, oligonucleotide synthesis, recombinant protein expression, and recombinant antibody preparation, meeting diverse biological research needs.
  • Other customized modifications: Including standard product customization, fluorescent labeling, and stable isotope compound customization to realize personalized product development.

2. One-stop Drug Screening & Technical Services
MCE builds a comprehensive drug screening platform, integrating artificial intelligence simulation and multi-dimensional experimental verification to provide full-process technical support for target verification and lead compound discovery:

  • In silico & AI screening: Virtual screening, AI drug screening, and molecular dynamics simulation to improve screening efficiency.
  • High-throughput biological screening: SPR molecular interaction detection, DEL synthesis and screening, affinity mass spectrometry screening, cell phenotypic activity screening, and targeted screening for GPCR, kinase, ion channel, nuclear receptorand other mainstream drug targets.
  • Pharmaceutical R&D optimization services: Professional target identification and lead compound optimization services to help customers rapidly iterate and optimize candidate compounds.

3. Quality System & Service Advantages
MCE strictly controls the whole production and service process with standardized quality management systems to ensure product stability, traceability and compliance:

  • Authorized certification: Equipped with ISO 9001 and GMP certified production bases, realizing standardized production management.
  • Comprehensive quality inspection: Adopting multiple advanced detection technologies including NMR, LC-MS, GC-MS and ICP-MS to provide complete quality test reports.
  • Flexible customized solutions: Supports bulk product customization and off-list product development, with an experienced team of senior scientists optimizing synthetic routes and reducing R&D costs.
  • Global compliant delivery: Provides complete customs declaration and compliance documents, supporting global transportation and meeting the research import requirements of various regions (such as ROECYT program in Argentina).

4. Application Fields
MCE’s customized products and technical services are widely applied in biomedical research, covering oncology, infectious diseases, autoimmune diseases, diabetes, cardiovascular diseases, neurodegenerative diseases and other core research fields, fully supporting basic scientific research and preclinical drug development for global universities, research institutions and pharmaceutical enterprises.)

More about MedChemExpress (MCE)

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