Cell4Pharma is a provider of state-of-the-art vesicular transport assays and nephrotoxicity screening assays for the pharmaceutical and biotechnology industries.
Cell4Pharma provides Vesicular Transport Assays to support drug-drug interaction and substrate studies. These assays utilize human drug efflux transporters (ABC transporters), which are transiently overexpressed in human embryonic kidney (HEK293) cells. Inside-out membrane vesicles derived from these cells enable high-throughput applications, ensuring reproducible and reliable results.
Cell4Pharma offers FluoPgp, an innovative fluorescent substrate designed for improved sensitivity and assay performance.
For reliable vesicular transport solutions, Cell4Pharma delivers high-quality assay components tailored for pharmaceutical and biomedical research.
Cell4Pharma’s vesicles offer an unmatched dynamic range compared to other solutions on the market, ensuring higher sensitivity and reliability for drug transport studies. Their high-quality vesicles are available for a range of key efflux transporters, including:
With Cell4Pharma’s vesicular transport solutions, researchers can achieve superior performance in drug-drug interaction and substrate studies.
Cell4Pharma’s mission is to reduce the number of drug failures due to renal toxicity during the clinical phase of drug development.
They envision a world without the risk of renal toxicity for compounds entering the clinical phase of drug development. Cell4Pharma aims to reduce the rate of late-stage clinical failures due to renal toxicity to below 3% market-wide within the next 10 years. Without the use of animal testing. This ambition is supported by their human renal cell lines; ciPTEC, validated through extensive collaborations with the pharmaceutical industry. More than 10 years of research have led to the development of robust cell-based assays focused on the detection of highly specific biomarkers of renal toxicity. ciPTEC consists of three cell lines.
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El-Sheikh, AK et al. Interaction of immunosuppressive drugs with human organic anion transporter (OAT) 1 and OAT3, and multidrug resistance-associated protein (MRP) 2 and MRP4
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Van der Made TK et al. Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease.
Nieskens TT et al. Expression of organic anion transporter 1 or 3 in human kidney proximal tubule cells reduces cisplatin sensitivity.
Caetano-Pinto P. et al. Fluorescence based transport assays revisited in a human renal proximal tubule cell line.
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