AdipoGen Life Sciences

Innovative and high quality products focusing on advanced inflammation, immune response & immunometabolic research.

AdipoGen Life Sciences, Inc. is an established manufacturer and global distributor of innovative and high quality products.

They focus on inflammation and immune response, including inflammasomes, innate immunity, B- and T-cell immune regulation, neuroinflammation, obesity and immuno-oncology. AdipoGen Life Sciences has chemical laboratories that enable the company to isolate unique natural products, develop new and innovative small molecules, and produce rare antibiotics.

AdipoGen Life Sciences works with a number of manufacturers such as: Ancell Corporation, ChemodexChimerigen LaboratoriesInnaxonJaICA, RevMAb Biosciences, and South Bay Bio.

Bio-Connect Life Sciences supplies all their products in the Benelux. If you have any questions, please contact us.

USPs and key product lines of AdipoGen Life Sciences

  • Antibodies (Special focus: functional antibodies & recombinant antibodies)
  • Recombinant proteins with enhanced activity and stability
  • ELISA kits & matched pair detection sets
  • Small molecules (biochemicals) / natural products / rare antibiotics
  • Animal-free production
  • Certified CHO/HEK cell lines
  • InVivoKines™
  • B-Xpander™
  • TR-FRET kit development

Featured Products

1. The Experts in Inflammasome Research

AdipoGen Life Sciences offers STANDARD KO-extract validated Antibodies / Activators and Inhibitors.

  • MultimericCD40L – Highly potent B Cell expansion reagent

Inflammasomes are multi-protein complexes whose activity has been implicated in both physiological and pathological inflammation. The hallmarks of inflammasome activation include the maturation of the cytokines IL-1β and IL-18, and the processing of gasdermin D to mediate cytokine release and pyroptosis from cells of the innate immune system.

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2. Multimeric CD40L – Highly potent B Cell expansion reagent

Also available in GMP-like format for preclinical cell therapy studies: B-Xpander™ – Unleash the power of B Cell Expansion

B-Xpander™ is a potent enhanced Multimeric human CD40L cytokine, for B cell activation, B cell expansion (proliferation) and cell therapy applications. In-house production using a proprietary protocol and a characterized and certified CHO cell line allows the supply of the most active Multimeric human CD40L proteins in GMP-like format.

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3. InVivoKines™

Proteins with Enhanced Activity & Stability for lnVivo Research

lnVivoKines™ are a new generation of recombinant fusion proteins for immunotherapeutic, preclinical and translational in vivo research, developed in-house by AdipoGen Life Sciences. lnVivoKines™ are Fc-based fusion proteins using the Knobs-into-Holes (KlH) technology.

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lnVivoKines™ Quality Features
  • Native Conformation – Production in HEK 293 or CHO cells
  • Production under Animal-Free Conditions
  • High Bioactivity tested by ELISA/Cell-based Assays
  • Verified Purity & Homogeneity by SEC
  • Low Endotoxin Levels
  • Batch-to-Batch Consistency
Featured InVivoKine™:

IL-12 (mouse):Fc-KIH (human) (rec.): AdipoGen’s new InVivoKine IL-12 (mouse):Fc-KIH (human) (rec.) has been shown to produce spectacular results. The injections in mice resulted in the complete cessation of tumor growth.

Publications

  • Eur J Immunol. 2017;47(6):1075-1085

    Haselmayer P, Vigolo M, Nys J, Schneider P, Hess H. A mouse model of systemic lupus erythematosus responds better to soluble TACI than to soluble BAFFR, correlating with depletion of plasma cells.

  • J Biol Chem. 2016;291(38):19826-19834.

    Kowalczyk-Quintas C, Schuepbach-Mallepell S, Vigolo M, et al. Antibodies that block or activate mouse b cell activating factor of the tumor necrosis factor (Tnf) family (Baff), respectively, induce b cell depletion or b cell hyperplasia.

  • Front Cell Dev Biol. 2020;8:577662.

    Eslami M, Meinl E, Eibel H, et al. Baff 60-mer, and differential baff 60-mer dissociating activities in human serum, cord blood and cerebrospinal fluid.

  • Front Immunol. 2021;12:651048.

    Kume M, Kiyohara E, Matsumura Y, et al. Ganglioside gd3 may suppress the functional activities of benign skin t cells in cutaneous t-cell lymphoma.

  • Sci Rep. 2015;5:12633.

    Singh K, Kadesjö E, Lindroos J, et al. Interleukin-35 administration counteracts established murine type 1 diabetes–possible involvement of regulatory T cells.

  • Sci Immunol. 2017;2(8).

    Ellisdon AM, Nold-Petry CA, D’Andrea L, et al. Homodimerization attenuates the anti-inflammatory activity of interleukin-37.

  • Nature. 2019;575(7784):669-673.

    Ising C, Venegas C, Zhang S, et al. NLRP3 inflammasome activation drives tau pathology.

  • J Virol Methods. 2021;292:114122.

    Müller K, Girl P, von Buttlar H, Dobler G, Wölfel R. Comparison of two commercial surrogate ELISAs to detect a neutralising antibody response to SARS-CoV-2.

  • Cell. 2020;181(3):674-687.e13.

    Zheng M, Karki R, Vogel P, Kanneganti T-D. Caspase-6 is a key regulator of innate immunity, inflammasome activation, and host defense.

  • Neurobiol Aging. 2020;91:167.e1-167.e9.

    Sellami L, Rucheton B, Ben Younes I, et al. Plasma progranulin levels for frontotemporal dementia in clinical practice: a 10-year French experience.

  • Cell Rep. 2017;21(13):3846-3859.

    Schneider KS, Groß CJ, Dreier RF, et al. The inflammasome drives gsdmd-independent secondary pyroptosis and il-1 release in the absence of caspase-1 protease activity.

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