α-Klotho

α-Klotho (Alpha Klotho) is a transmembrane protein, confirmed its expression in the kidneys and the parathyroid glands. In recent years, it has become clear that α-Klotho is an important molecule within a living organism regulating the metabolism of mineral such as calcium and phosphorus.

α-Klotho assay kits by IBL Japan

Specifically detect – Human secreted α-Klotho isoform

The α-Klotho gene was identified as a gene with extremely reduced expression in genetically mutated mice with a phenotype that closely resembles the diverse aging symptoms of humans.

The long N-terminal extracellular domain, which occupies most of the sequence of the α-Klotho protein, has been reported to be shedding and released in the blood, while secretory isoform with only first repeat by gene splicing (secreted α-Klotho) has been reported.

Secreted α-Klotho

This kit specifically measures human secreted isoforms (secreted α-Klotho) in human serum, EDTA-plasma and cerebrospinal fluid (CSF) and does not react with soluble α-Klotho derived from transmembrane α-Klotho.

Since there are many unclear points regarding the function of secreted α-Klotho protein and its body fluids concentration, we hope the kit will contribute further research of secreted α-Klotho.

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