Idylle is the tool development partner for researchers. Idylle co-develops, manufactures and delivers research tools, all designed by academic researchers.
FakirSlide are ready-to-use coverslips patterned with micro- and nano-structures to induce diverse, well-controlled topological cues on live cells or planar model membranes.
Made of borosilicate glass, they are compatible with all types of advanced microscopies and provide a solid support allowing for long-term experiments.
Fakirslides substrates have been successfully used to manipulate membrane morphology of living cells and supported lipid bilayers, and observe effects of curvatures on membrane protein dynamics, cytoskeletal reorganization and cell migration.
Unlock new insights!
Based on a newly-developed nanostructuration technique called soft nanoimprint lithography, FakirSlide pushes the resolution boundaries and makes available to researchers a diverse panel of reproducible micro to nano-scale topographies of various aspect ratios to better investigate key cellular responses to specific membrane topologies.
Maximize assays reliability
FakirSlide provides ordered arrays of structures with high control over their shape, diameter and periodicity. They were specifically designed to induce robust & consistent membrane curvatures and facilitate data analysis.
Simplify the workflows
made of a high-quality synthetic silica layer, the Fakirslide surface is directly functional for supported lipid bilayers without the need for harsh cleaning or hydroxylating pre-treatments.
A technology developed by Laura Picas (IRIM UMR9004), Adrian Carretero (IES UMR5214), Raissa Rathar (IRIM UMR9004 & IES UMR5214) & David Sanchez (IES UMR5214) – Montpellier, France
Stencell – Removable PDMS cell culture chambers
Stencell are ready-to-use silicon chambers that you can stick and remove for cellular confinement or dynamic assays, such as migration or wound-healing. Stencell was designed to standardize your experiments and minimize the consumption of reagents.
It is very helpful when you are working with super expensive reagents or very rare cell lines, and when you want to test various experimental hypothesis.
Applications of Stencell
Cell migration and wound healing with Presto and Allegro
Interaction dominant/dominated cells
Defined regions of Rab5A overexpression
Parallelized experiments with Quartet and Nonet
Differentiation of stem cells or zebrafish embryonic cells
Cell behavior in confined conditions
Confined experiments with Solo
Fixed epithelial cells growing confluent
Stencell was designed by Vincent Studer, Pierre-Olivier Strale and Aurélien Pasturel.
Stampwell U-Shape are 3D-printed stamps designed to easily create U-bottom wells in any type of hydrogels such as agarose, alginate, phytagel, methycellulose, …). This forms an array of non-adherent wells in which cell suspension can be loaded to watch cell aggregate in individual 3D cell structures.
The same stamp with flat bottom wells has been designed to be able to better image the spheroids.
Key features
Samples immobilized on a similar focal plane
Compatible with a wide variety of hydrogels
Reusable
Cost-Saving compared to low-adherent well-plates such as ULA
SpheroTribe is a concentrated polymer-based solution that increases the medium viscosity, therefore favouring cell-cell contacts. It offers a simple method to generate homogeneous 3D cell structures with increased control over their shape, minimizing variability between samples and improving the consistency of your downstream experiments such as migration/invasion assays, immunostaining, drug screening or in vivo implantation experiments. SpheroTribe is particularly useful to boost aggregation when working with challenging cells.
Key features
Cell aggregation booster
Increased homogeneity
Easy to use: simply dilute it in your culture media
No need to work on ice
Developed by: Gaëlle Recher and Camille Douillet (CNRS – Université de Bordeaux, France)
AgarSqueezer to mimic the compression of a real cell environment
Principle
AgarSqueezer is an innovative cell culture system to grow and image cells under different confinement levels within a physiological rigidity range (1-150 kPa). The confinement system is based on molded agarose pillars, which enables an instant & homogeneous compression on cells, to study their response to short and long-term confinement up to 10 days.
Key features
Homogeneous cell confinement
Tunable pressure in a physiological range: 1-150 kPa
Physiological rigidity
Open access to the reservoir: Possibility to add drugs, and reagents, easy medium renewal.
Long term confinement
Fully compatible with multiple microscopy techniques
Easy to recover coverslip with cells for subsequent molecular analysis: FACS, qPCR, Western-Blot, Immunofluorescence (possible in situ)
Developed by: Audrey Prunet, Gilles Simon, Hélène Delanoë-Ayari, Véronique Maguer-Satta and Charlotte Rivière.
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