The Year of the Cytocentric Bioreactor!

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As 3D hollow fiber perfusion bioreactors are increasingly recognized as superior to and more in vivo like than traditional 2D flask culture methods, we are proud to champion a new era in cell culture technology.

3D high-density culture in a hollow fiber bioreactor not only supports these cytocentric principles, but also takes them a step further by allowing the cells themselves to create their own specific microenvironment. This promotes proper cell physiology and creates an environment that mimics of in vivo conditions. As a result, it facilitates complete and uniform post-translational modifications while preserving bioactivity and cell physiology. The auto-support provided by cell-secreted cytokines is what enables FiberCell’s CDM HD, a chemically defined medium for high-density culture, to achieve near-universal efficacy with a simplified formulation.

Technical advantages of FiberCell Systems

1. LESS DISRUPTION, LESS WORK & LESS WASTE
   Maintenance is only 15 minutes a day. Passage numbers are irrelevant when you can achieve continuous cell culture production for many months, as splitting of cells is not required.
2. CLEAN, CONCENTRATED & SIMPLIFIED HARVEST
   HFBRs allow 10-100X higher concentration of secreted products, and reduced apoptosis and shear on cells. This results in significantly lower host cell protein and DNA contamination, along with reduced membrane fragments.
3. UNIQUE 3-D POROUS SUPPORT
   Enables in vivo like conditions for optimal, high-density cell cultivation and cell co-cultivation. Fiber geometry mimics the mammalian capillary bed.
   

FiberCell’s system can be used for a wide variety of applications

Discover the real power of Hollow Fiber Cell Culture. Learn more about their full range of applications.

• Recombinant Proteins
• Monoclonal Antibodies
• Antibiotic PK/PD
• Exosomes
• 3D Cell Culture

FiberCell’s Cell Culture Manual

Please also take a look into FiberCell’s brand new Cell Culture Manual which is packed with updated protocols for hybridoma culture, recombinant protein production, cell co-cultivation, mesenchymal stem cell culture, and exosome production. Dive into decades of expertise distilled into one comprehensive guide.