Nuclear factor kappa beta (NF-kB) signaling pathway consist of proteins that function as transcription factors that regulate expression of genes, and therefore influencing a broad range of biological processes including immune response, inflammation and cell proliferation. Stimuli such as cellularstress, cytokines, free radicals, UV radiation, oxidized LDL, and bacterial or viral antigens activates this pathway.
Activated NF-kB complexes are translocated to the nucleus where it binds to specific sequences of DNA called response elements to induce target gene expresion. Incorrect regulation of the NF-kB signaling pathway might lead to disease including cancer, inflammatory and autoimmune diseases, viral infections, improper immune development.
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