Factor deficient plasmas

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This news was updated in March 2025.

Coagulation factor deficient plasma

Prolytix’s (Haematologic Technologies) coagulation factor deficient plasmas are for research use or for further manufacture into in vitro diagnostic (IVD) reagents. These deficient plasmas are manufactured from citrated “coagulation normal” human plasma and are immunodepleted of the target coagulation protein. One exception is factor VIII deficient plasma, which is chemically depleted of factor VIII activity while retaining normal antigen content (i.e. CRIM+ plasma). Each lot of plasma is assayed to ensure that the activity of the remaining factors is 50 – 150 %, and is tested for fibrinogen level, PT, aPTT, and clarity. Custom specifications can also be accommodated.

The deficient plasmas currently available are: factors II, V, VII, VIII, IX, X, XI and XII and antithrombin III. Upon request, Prolytix also manufactures double-deficient plasma where the plasma is depleted of two coagulation proteins. All deficient plasmas are available in 1 and 50 mL vials for research applications. Please inquire about custom and bulk aliquot sizes.

Prolytix (Haematologic Technologies) factor deficient plasmas are calibrated against IVD plasmas to ensure equivalent performance – all for about half the cost of IVD deficient plasma. They are shipped frozen on dry ice and have a 5 year shelf-life when stored continuously at –70°C or colder.

Recent publications using Prolytix factor deficient plasma

1. Smith, S., Blood. 2008 112: 2810-2816 (Prothrombin deficient plasma)
2. Tucker, E., et al., Blood. 2009 113: 936-944 (Factor XII deficient plasma)

This publication list is not all encompassing and is only meant to provide limited examples of how Prolytix (Haematologic Technologies) products are used. We encourage you to search the literature for other examples pertinent to your experimentation, and to contact us with any technical questions.

Prolytix (Haematologic Technologies) has been providing customers with high quality research reagents and custom collection devices since 1987. Visit their supplier page to learn more about these reagents and others in Prolytix extensive product catalog.