FiberCell Systems

A hollow fiber bioreactor is the most in vivo like way to culture cells. The 3-D perfusion architecture and high cell density mimics the capillary bed and allows cells to generate their own micro-environment. They are fundamentally different from any other way of culturing cells in three important ways.

• High surface area to volume ratio.
• More cells in less space.
• Less maintenance

Concentrated secreted products

Chemically defined medium

FiberCell Systems offers chemically defined protein-free media supplement specifically optimized for high density cultures. The CDM-HD media comes as a powder that can be reconstituted, offering cost savings and easier storage.

Monoclonal antibody and recombinant protein production

A hollow fiber bioreactor is the ideal method for the production of 50 mgs on up to gram quantities of a monoclonal antibody or recombinant protein from a stable transfectant. Secreted products are up to 100X more concentrated, membrane fragments and host cell protein contamination is reduced, and when used with FiberCell’s CDM HD protein free medium your secreted product of interest can be the predominant protein in your harvested supernatant. This can simplify purification and sometimes increase yield.

Exosome production

Many publications demonstrate the advantages of production extracellular vesicles in a 3-D hollow fiber bioreactor. Large numbers of cells can be cultured in a compact space and secreted EVs are concentrated. Some publications show enhanced bioactivity of EVs when produced in a hollow fiber bioreactor.

Bio-Connect supplies all their products in Europe. If you have any questions, please contact the helpdesk.