Cygnus Custom Development Services

Cygnus Technologies specializes in host cell protein (HCP) and DNA impurity detection. In addition to their catalog kits, they provide customized antibody and assay development services for HCP and DNA detection in recombinant biopharmaceuticals. Using their proprietary technologies, they generate and affinity purify sensitive and broadly reactive polyclonal antibodies. They have now successfully developed over fifty ELISAs for various recombinant expression systems, including bacteria, various yeasts, human and mammalian cell lines, as well as transgenic and plant expression systems.

Through their extensive networking with other high-quality special technology companies, they can integrate and manage projects requiring highly diverse technical inputs.

Custom antibody & assay development

Proven antibody generation and purification technologies to help you develop, qualify and manufacture a robust kit to meet your specific process, testing and regulatory needs.

• Antibody production / assay development
• Custom DNA assay development

Assay qualification & coverage analysis

Comprehensive qualification of your in-house assays or generic kits with state-of-the-art orthogonal methods (AAE, mass spectrometry, western blotting) to meet global regulatory requirements.

• Dilution linearity & spike recovery
• Orthogonal coverage analysis by AAE™
• Orthogonal coverage analysis by 2D PAGE
• Orthogonal coverage analysis by Mass Spectrometry

Antibody development

Development of poly- or monoclonal antibodies – includes immunogen synthesis and conjugation, as well as identification and synthesis of peptide antigens.

• Custom antigen production & preparation
• Antibody production
• Antibody purification & characterization

Sample testing

Sample testing by ELISA and other orthogonal methods for host cell proteins that might co-purify with your product.

• Sample testing by Mass Spectrometry
• Sample testing by ELISA
• Sample testing by AAE™

Need more information?

Learn more about the Cygnus services on their website or if you have any questions you can contact our technical support.