Advanced Exosome Production Technology from FiberCell Systems

FiberCell Systems is at the forefront of biotechnology with its advanced 3D hollow fiber bioreactors, designed for the efficient production of extracellular vesicles (EVs) and exosomes from mammalian cells. This state-of-the-art technology closely mimics in vivo conditions, ensuring the production of high-quality EVs and exosomes that are free from contaminating serum EVs. The use of a protein-free CDM HD serum replacement further enhances the purity and consistency of the output.

Unlocking the potential of exosomes for regenerative therapies has been challenging due to production limitations. However, a breakthrough lies in 3D perfusion hollow fiber bioreactors, offering a pathway to generate clinically significant quantities of extracellular vesicles in a cGMP compliant setting. A recent study showcases the potential of the FiberCell Bioreactor for large-scale biomanufacturing to produce natural killer cells and their derived extracellular vesicles in cancer immunotherapy, further underscoring the bioreactor’s capabilities. Here is the link to the article.

FiberCell Systems bioreactors allow for continuous, daily harvesting over extended periods, ranging from weeks to months, making them a reliable choice for researchers. The effectiveness of the technology is well-documented in numerous publications, demonstrating its versatility across various cell types, including mesenchymal stem cells (MSCs), human amniotic fluid stem cells, 293 cells, primary cancer cell lines, and natural killer (NK) cells.

The accompanying image, provided by Dr. Jeffrey Franklin from Vanderbilt University, illustrates an ultracentrifugation pellet of EVs collected using the C2011 cartridge, showcasing the groundbreaking results achievable with this innovative technology.

• Use the latest technology from FiberCell Systems to improve your research. Enhance your scientific endeavors today!
• If you’re looking for a comprehensive overview of exosome production methodologies, you can download the white paper here.